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Universidade de Vigo CITI |
“We are very satisfied with the disrupter. It’s equipment is very easy to use and effective in breaking cells. I also would like to thank Constant System for for the assistance provided.” |
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Russian Cardiology Research and Production Complex |
“Constant Systems cell disrupters are successfully used at our Experimental plant mainly for bacterial cells. These efficient machines became an important part of our enzyme purification unit. We are very satisfied with the quality and reliability of Constant Systems disruption equipment. The disrupters are easy to operate and do maintenance. We thank you for friendly after sale support, information interchange and service.” |
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IPLA |
“The Constant Systems cell disruptor has made extraction of membrane proteins from Gram positives a reproducible and efficient task in our lab. ” |
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Deva Holdings |
“I can honestly say that Constant system cell disrupter and their services are amazing. For breaking bacteria cells , our first choice is always Constant System cell disrupter.” |
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Wellcome Trust Sanger Institute |
“An excellent and versatile solution to our bacterial cell disruption applications, backed up by high levels of service from Constant Systems.” |
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University of Copenhagen |
“We think that the Constant Systems cell disruptor is a very powerful and timesaving tool in breaking both yeast cells and bacterial cells. It also excels in reliability of operation.” |
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BIONEER A/S |
“We have had our Cell Disrupter (TS Series Bench Top) for less than a year, and we cannot understand how we were managing without it. The reproducibility of the process is an important advantage compared to the systems we worked with before. We use it for releasing heterologous proteins from E. coli as soluble product as wells in inclusion bodies. With the One Shot Head Adapter we can disrupt cells from small scale flask experiments, and in continuous mode we have used the machine for processing material from high density fermentations in 10 liter scale. The support from Constant Systems has been fast and efficient whenever we needed advice on technical matters.” |
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Dako A/S IHC Reagent Development |
“Our Constant Systems Cell Disruptor (TS Series Model)is a reliable workhorse in the laboratory, consistently producing excellent lysis results and requiring very little maintenance. It can process rather small volumes of bacterial cultures as well as fermentation batches in an equally efficient manner. I have used several different methods and solutions for cell lysis and this is definitely my preferred solution of choice.” |
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University of Copenhagen |
“We have had the cell disrupter from constant system for the last 9 years and are very pleased with it. We process 2x2½L of e coli homogenate twice a week, the homogenization is done in ½ hrs, which is a whole lot faster than the chemical/enzymatic process that we used before. The high pressure does wear the O-rings down, but shifting them is now done as a maintenance on a regular basis by our technician. I am not sure what we should do without it.” |
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University of Copenhagen |
“We use the cell disruptor for mainly E. coli and insect cells. We are finding it very versatile since we use it for a lot of different strains. The results are always reproducible and reliable. Furthermore it's very easy to use.” |
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Dublin City University |
“The Constant System cell disruptor is our first choice for cell lysis in our scaled protein production procedure. The instrument is reliable, easy to use and has enabled us to achieve consistent and total lysis of our prokaryotic cells. This has enhanced the performance and efficiency of our process.” |
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ACS DOBFAR SpA |
“We use the Constant System Cell disruptor about three/ten times on month in breaking for bacteria cells. We are very satisfied with its performance and ease of use.” |
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ICGEB |
“As a scientist in the Biotechnology Development Group at the ICGEB, Trieste, Italy I am involved in technology transfer activity to many biotech companies in the developing countries. We are using Constant disruption systems in all processes and we are pleased to use them as very reliable, complete and accurate equipment. They are easy to use machines that meet all our process demands. We have been impressed with the services and excellent response time to our needs. Constant Systems team is friendly and easy to deal with. The company is very professional with Constant willing to improve their activities. Our guests experience is in complete accordance with our own.” |
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University of Milan |
"We use the cell disrupter with bifidobacteria, lactic acid bacteria, and a number of non-conventional yeasts. The cell disrupter is very effective and timesaving" |
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University of Modena & Reggio Emilia |
"We use the cell disrupter with bifidobacteria, lactic acid bacteria, and a number of non-conventional yeasts. The cell disrupter is very effective and timesaving" |
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University of Novara |
“The Constant Systems Basic Z disruption system is our first option for bacterial cells lysis during large-scale protein purification procedures.” |
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Wageningen University |
“The cell disruptor from Constant Systems is an easy to use and simple piece of equipment. It proved a very useful tool for the fast and efficient lysis of gram positive as well as gram negative bacterial cells. It has become an important instrument in our daily experimental routines.” |
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Chimmed - Russian Cardiology Department and Production Complex |
“Constant Systems cell disrupter is successfully used at our Experimental plant mainly for bacterial cells. This efficient and reliable piece of equipment became an important part of our enzyme purification unit.” |
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Biokit |
“We routinely use the Constant Systems cell disruptor for bacteria and yeast cells. We are very satisfied with its performance and ease of use.” |
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IRB |
"We have been using our 1.1kW model for the last three years to disrupt E.coli, Mammalian, Insect and Yeast cells and we are very pleased with it. The disruptor handles all of these cell types with ease and delivers efficient and reproducible lysis results that allow us to prepare high quality proteins. It has been so successful, even with membrane protein preparations, that researchers from almost every other lab in the institute come to use it." |
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Institute of Chemical and Environmental Research |
"We have routinely used the TS Series 0.75 KW Benchtop cell disruptor with bacteria and yeast cultures for 4 years. The results and reliability of the system, as well as the response from Constant Systems whenever we needed, have satisfied all our expectations." |
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University of Valladolid |
"We use the Constant Systems cell disruptor for bacteria cells. We are very satisfied with its performance and ease of use. Really, it has been converted to a very powerful and timesaving tool in our routinely purification process." |
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IBMB |
"The Cell disrupter from Constant Systems has a key position in our laboratory routine. You can proceed your sample fast and efficient. Especially if you are working with samples that need to be disrupted at high pressure, there is no better solution at the moment. The service technicians have always listened to our problems and responded quickly, even if they are busy on the other side of the world." |
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Astra Zeneca |
“We routinely use the Constant Systems cell disruptor for insect cells, bacteria and yeast cells. We are very happy with its performance and ease of use.” |
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Swedish University of Agricultural Sciences |
“The Constant Systems cell disruptor gives the best results in breaking bacteria cells for isolation of membrane fractions compared to other methods. The system is easy to operate, the technical supports are extremely effective and friendly.” |
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University of Bath |
“The Constant Systems cell disruptor has been a robust and reliable piece of equipment that dramatically improved our cell lysis capabilities and protein recovery yields from bacterial production. Constant Systems also offers a great supporting service.” |
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Bristol University |
“Our group and several others are regular users of the Constant Systems cell disruptor primarily for bacterial cells. We find it to be an extremely efficient and robust piece of equipment, which is now an essential part of our protein production facility.” |
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De Montford University |
“We have used the Constant Systems machine for over 5 years for cost effective disruption of Yeast (brewers yeast) cells verses the expensive use of lyticase enzyme. Since we have used the machine with cultures from under 100ml to over 10 litres we have saved the cost of the machine verses the use of lyticase. It has reduced our processing times by removing long tedious steps of our previous method. After a few months of optimisation we were using the single shot and continuous flow adaptors interchangeably with confidence in so much that we were happy that the method produced material similar to previous methods. Our application requires maximum disruption of the biomass with minimal disruption to the endoplasmic reticulum and their related proteins. The machine is able to produce a suitable compromise and the ability to cool the samples is perhaps key to our ability to recover active protein. Before purchasing we looked at other mechanical methods of disruption these tended to require sample low volumes, had consumable elements, no temperature control and less control of the force of disruption. We took delivery on time and the servicing has been to professional standards. During demonstration and after purchase constant systems were able to offer some advice using the machine. Due to the robust nature of the equipment it tends to have no problems if used correctly. As far as we know at the time of purchase and now there is not a better machine for our application. ” |
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Diamond Light Source |
“I think the Constant Systems Cell disruptor is very efficient for breaking bacterial and yeast cells, it is very useful for our purpose. We are also very satisfied about the Customer service of Constant Systems, always patient, professional and respond quickly.” |
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Edinburgh University |
"We use the Constant Systems cell disruptor daily, for insect, mammalian, yeast and bacterial cells, in volumes from 1 ml to 100s of mls. We are extremely happy with its performance, reliability and ease of use. It is one of the most utilized instruments in the facility." |
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Edinburgh University |
"Our cell disruptor is used multiple times daily with everything from bacteria to plant extracts. It is an extremely reliable and robust instrument and the reproducibility of the lysis and the levels of extraction are excellent. It is probably the best value piece of instrumentation in the protein production labs. I'm very happy with it." |
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Glasgow University |
"The Constant Systems cell breaker gives highly efficient breakage of yeast cells and is our best option for isolating membranes from yeast." |
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Institute of Cancer Research |
"I have been continually impressed with Constant Systems Products for the past 5 years. They have successfully lysed all the organisms I have tried and with a minimum of fuss. The effeciency of lysis, ease of use and time saving is unparalleled for us. Furthermore, the service provided by Constant Systems has always been first rate, prompt and helpful. A delightful company to do business with." |
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John Innes Centre |
"We routinely use the Constant Systems cell disruptor for the most efficient disruption of bacteria. We are very satisfied with its performance and ease of use" |
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Lipoxen Technologies Ltd |
”We use a Constant Systems disruptor at ~40K psi for small Liposome (< 100nm ) production. We are very satisfied with its performance and flexibility regarding temperature control, it enables us to produce low CoG “empty” small Liposomes” |
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Molecular and Biochemical Parasitology - Liverpool School of Tropical Medicine |
"The Constant Systems Cell Disruptor is an asset to our laboratory, and a robust, reliable workhorse for the disruption of bacterial and fungal cultures." |
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MRC Laboratory of Molecular Biology |
"We routinely use the Constant Systems cell disruptor for bacterial protein production. We are very satisfied with its performance, customer service and ease of use." |
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NeuTec Pharma |
"The Constant System provides safe, fast, simple operation, and more over, excellent results in cell disruptions. It is also a very reliable equipment standing up for regular and frequent usages." |
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Newcastle Upon Tyne |
"I am happy with the machine and it does a good job in homogenizing E. coli and also with yeast. We use the one shot head for many samples with E. coli and I use the continuous flow head with up to 1 liter of S. cerevisiae yeast." |
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Research Complex at Harwell |
"We are extremely happy with our Cell disruptor, we use it for bacterial and yeast culture cells mainly. It is very easy to use and very reliable." |
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The Membrane Protein Lab at Diamond, part of Imperial College London |
"We use the Constant Systems cell disruptor for lysis of E. coli and S. cerevisiae cells as part of our work in preparing membrane proteins for structural studies. We find the system easy to use and effective." |
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Touchlight Genetics Ltd |
"We have the Constant Systems One Shot machine and in our opinion there is nothing to equal it on the market for cell disruption. We use it to break E. coli cells for recombinant protein production and it gives us quick, reproducible disruption. Everything from the initial machine demonstration through to ordering and delivery was easy and efficient (our machine was delivered ahead of schedule). We couldn’t fault their customer service, they even made us a custom part to improve our process! We cannot recommend it highly enough." Dr Lisa Caproni |
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UCB Celltech |
"We are very happy with the disruptor and routinely use it for lysis of bacterial cells. Compared with our previous French press method there is a 75% reduction in processing time. We would recommend this product." |
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University of Edinburgh |
"We have had two Constant Systems cell disrupters in our fermentation suite for several years. In this time dozens of users from diverse backgrounds have employed the cell disrupters to break tens or hundreds of grams of cells per use - all have obtained excellent breakage, and subsequently good yields of their proteins. New users require minimal instruction with these conceptually simple machines, cleaning is straightforward and service by Constant Systems is second to none." |
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University of Leeds |
"We took delivery of a TS Series 2.2kw disruptor system at the end of February 2011, for use in our research on bacterial and yeast membrane transport proteins. For our work we needed a means of disrupting cells from cultures ranging in volume from 1 to 100 L, in order to make preparations of membranes as the starting material for purification of the proteins. We wanted a machine that was efficient, straightforward to operate, reliable and suitable for use up to several times a day by multiple operators, as an adjunct to a microbial fermentation facility. Since its installation, the disruptor has been heavily used and we have been delighted by the quality of the preparations that it yields, its ease of use and, most importantly, its reliability. We have also been pleased with the very helpful advice on its use provided by Constant Systems, and by the quality of the service provided by the Constant Systems service engineer during the installation and routine maintenance visits. I can therefore highly recommend this machine – Professor Steve Baldwin, Astbury Centre for Structural Molecular Biology, University of Leeds" |
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University of Oxford - FAA Group |
"We use our Constant Systems cell disruptor for large-scale lysis of bacterial cells. The system is effective, highly consistent, easy-to-use, and much faster than other cell lysis systems. The staff at Constant Systems were very helpful during the installation and training" |
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National Institute for Medical Research |
"We've been using the same Constant Systems cell disrupter for over 10 years now and have achieved excellent results in disrupting yeast, bacterial and occasionally insect cells." |
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Cancer Research UK |
"Brilliant piece of equipment, from a brilliant company with great support in all areas. We can not ask for better. We use our Constant System's Cell disrupter to break 10-100L batches of bacterial and yeast cells grown in our fermentation facility." |
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University of Liverpool |
"We have been using our One Shot cell disruptor for 10 years now. It continues to be our method of choice for lysing bacteria and yeast samples'." |
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University of Oxford |
"We routinely use Constant Systems cell disruptor for breaking both bacteria and yeast cells, for the last four years. We are very satisfied with its performance and ease of use. We are also very satisfied with the Constant Systems customer support, response time and repair time." |
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Immunocore |
"Here in Immunocore we are using it on regular basis for disrupting bacterial cells that express our product as inclusion bodies. Very often I use it almost all day long and it is very reliable and the final product released from the cells is recovered to nearly 100% with very good quality. Also the service provided from you in maintaining the Cell disrupter is very good. Thank you for your help!" |
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University of Sheffield |
"We use the Constant Systems TS Series 2.2kw regularly to disrupt yeast and occasionally bacteria. It has proved to be reliable and efficient over a number of years. We have also found the technical support provided by the Constant Systems staff to be excellent" |
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Swansea University |
"The Centre for Complex Fluids Processing in the College of Engineering at Swansea University has a long history of collaboration with Constant Systems. The Centre uses the CS disrupter for processing a wide range of microorganisms, including bacteria, yeast and microalgae. The disrupter has proved itself to be a highly reliable and efficient tool for recovering intracellular materials produced at both laboratory and pilot scales." |
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University of Alberta |
"I think that the Constant Systems cell disruptor is a very powerful and timesaving tool.” |
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University of Western Ontario |
"The Constant System Disrupter has been in continuous use in my lab for two years. We have had no problems and the operation has been exactly as promised. We are very happy with the way that the unit disrupts E. coli bacteria cells in an efficient and reliable way.” |
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University of Toronto |
"We find the Constant Systems TS Series 0.75kw cell disrupter to be highly reliable and efficient in its lysis of bacterial cells. We use this system practically everyday and is extremely easy to use.” |
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University of Alberta |
"I find this Cell Disruptor to be the easiest, most efficient way of lysing bacteria, yeast and algae I am familiar with. It saves us time and money and is easy to use and maintain.” |
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University of Alberta |
"We are happy with the performance of the Constant System Disruptor. It is very efficient in lysing both bacterial and yeast cultures without any issues.” |
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University of Saskatchewan |
"Our TS 0.75KW model is reliable, robust, easy to use and clean. Results are reproducible. Costumer service is excellent. Problems are solved professional and in due time. Students, technical personnel and PI’s are happy with the purchase of this instrument and appreciate the investment every day. What more can you ask for in a scientific setting.” |
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Université de Montréal |
"The cell disruptor has been quick, easy to use and clean and efficient at bacterial cell lysis and meant that we no longer have to depend upon accessing French press.” |
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University of Saskatchewan |
"We are very pleased with the Constant Systems Cell Disrupter. It is a very fast operating, reliable, safe and robust instrument. It can easily be used by students and technical personnel alike without extensive training or prior lab experience, which makes it perfect for teaching and research facilities that deal with a large number of users of different background.The relatively small footprint of the instrument is a huge bonus. Customer Service is excellent and arising questions are dealt with quickly and efficiently. Suggestions for improvement are welcome, which shows attention to customer needs." |
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University of Alabama at Birmingham |
“We routinely use the Constant Systems 1.1 kW cell disruptor for bacteria and yeast cells. We are very satisfied with its performance and ease of use." |
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Burnham Institute for Medical Research |
“We have tried a variety of methods to disrupt yeast including manual grinding and a mixer mill and the One Shot outperforms them all. We’re very satisfied with the instrument and would recommend it to anyone wanting to generate high quality extracts from hard to lyse organisms.” |
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Cornell University |
“We routinely use the Constant Systems cell disruptor for bacteria, mycobacteria, and yeast cells. We are very satisfied with its performance and ease of use”. Most of all, if we have questions, and call the company, they always help us to solve the problem.” |
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Dow Chemical Company |
“I'd like to thank you for your responsiveness and help in walking us through this week's experience with the disrupter. Should you need a reference in the future for a prospective client, by all means, please have them call on us. It's this type of customer service and good product that has value in the marketplace.” |
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Sanofi Aventis |
“We are extremely pleased with our Cell Disrupter. We have used different systems in the past but none of them comes close to this system with regard to :1) User friendliness :- a) --set pressure and press the button b) -very easy to clean and sanitize 2) Flexibility and Effectiveness: a) --provides a wide range of pressures for lysing different cell types b) --a single pass is all that is needed to lyse 100% of suspended E.coli cells 3) Robustness_ This is a well engineered sytstem--we have not experienced any break down or down time 4) Service (maintenance) is excellent” |
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The Scipps Research Institute |
“The Constant Systems cell disruptor allows us to process 10L of yeast in an hour with a single pass, while retaining a cool temperature. This technology enables us to produce more recombinant protein and address complex biological problems.” |
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University of Kansas |
“Comparing to all the cell disruption methods I have used, Constant Systems cell disruptor is the best!” Philip Gao, Ph. D. |
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University of Michigan |
“The cell disruptor is a really good equipment for breaking yeast, bacteria cells, and plants. We bought the one shot adapter which is really easy to add to the cell disrupter and the system works great. We have with the cell disrupter a very efficient system.” |
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Ohio State University |
“I have had good experiences when using the homogenizer. It has good efficiency and I have never had to run a sample through twice to get proper cell lysis.” |
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Massachusetts Institute of Technology |
“We are extremely satisfied with the Constant System cell disruptor which allows us to open bacterial cells in a very efficient and high through put way. We are also were satisfied with the in-line cooling system that ensures that your protein purification is done at the most gentle way.” |
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Baylor College of Medicine |
“This is one piece of equipment that every structural biology lab got to have! Cell lysis is thorough, easy, clean, quick and humane. The service staffs are highly professional and responsive. Andy and Kaylee make sure my cell disruptor is working all the time. Some of insoluble samples prepared by other cell lysis methods turned out to be fine once we process them using the cell disruptor. We also know that this method of cell lysis does not compromise protein's native fold because our group obtained several protein crystals and solved five crystal structures using the sample processed by the cell disruptor!” |
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Pioneer Hi-Bred International, Inc |
“We replaced our French Press with a Constant Systems homogenizer about two years ago. It was one of the best acquisitions we have ever made. The instrument is used on an almost daily basis and works well for a variety of microbes. It has saved us time to process large sample volumes in a single pass and added more consistency to our preparations, because the temperature is much better controlled compared to the chilled French Press cell we’ve used before. Overall a very reliable and trouble-free experience” |
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Monsanto Company |
“The Constant Systems cell disruptor break bacteria cells very efficiently, and it is easy to operate. We use it as a routine method in our lab to break bacteria cells at all different scales” |
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Kapa Biosystems |
"Because of the efficiency and reliability demonstrated by the Constant Systems cell disruptor, it is our method of choice for bacterial cell lysis during routine, large-scale protein production." |
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Lanzhou Institute of Biological Products |
"We think that the Constant Systems cell disruptor is a very powerful and timesaving tool in breaking both yeast cells and bacterial cells. The results are always reproducible and reliable. Furthermore it's very easy to use." |
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Shanghai Institute of Biological Products |
"Our TS2.2KW model has been in continuous use for four years. It's very easy to use and fast operation." |
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Shenzhen University |
"We use the Constant Systems cell disruptor for plant leaves and we are satisfied with its ease of use and efficiency." |
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National University of Singapore, Centre for Life Sciences |
"We've recently acquired a Constant Systems One Shot system and primarily use it for E. coli cell disruption as the initial step in inclusion body and soluble protein purification. The system is safe and simple to operate, and lysis results are reliable and consistent. All lab members readily adopted it in their routine bacterial protein production as it saves a lot of time compared to previously used protocols." |
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Cowell Medi |
"I just can operate this system with only one button. Cleaning is really simple and perfect. I’m satisfied with Constant Systems." |
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Seoul National University |
"Very simple and easy to use. Simplest machine in the world!" |
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Sungkyunkwan University |
"It is very easy and stable system even for a beginner." |
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Academia Sinica |
"The Constant Systems Cell Disruptor is highly efficient breakage of bacteria and yeast cells, and very fast. It is easy to use and save us a lot of time." |
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National Taiwan University |
"Constant Systems cell disruptor is fast and easy to use for bacteria and yeast disruption. It helps us a lot for our protein research." |
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Pontifícia Universidade Católica do Rio Grande do Sul<br />Centro de Pesquisas em Biologia Molecular e Funcional |
"What we could say about Constant Systems is that you provided us with equipment that we trust. It's simple, easy to use, easy to clean, and reliable. And besides the fact that the machine deliver the goods, Constant Systems always promptly replied to our needs being very kind and considerate in solving our problems." |
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Cedive |
"Constant systems cell disruptor is easy to perform and safe, we work with mycobacteria a very harsh microorganism, one shot model produces bacterial cell lysis, releasing high quality antigen with a sufficient amount of proper material for antigen research." |
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University of Adelaide |
"We use the Constant Systems cell disruptor for bacterial cells and are satisfied with its ease of use and efficiency." |
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Flinders University |
"We use the Constant Systems Cell Disrupter on an almost daily basis and found it to be by far the best, easiest to use and time efficient way to crack open bacterial cells." |